We R the Cure

Seeking Cures and Cheating Destiny

The “Highs and Lows” Of Type 1 Diabetes Clinical Trials: Some Days You’re the Windshield; Some Days You’re The Bug

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LauraRNMike2

Laura Kollar, right, Clinical Research Coordinator and Nurse Manager at UVA, spent her Saturday morning guiding the health screening for trial participants at Barringer Wing. Thanks Laura!

As I ponder the current ” Ups and Downs” of my participation in a new Type 1 Diabetes Clinical Trial at UVA, two quotes come to mind. One comes from a famous figure in American history; The other comes from my father, a UVA alum known for his wit and wisdom throughout the Anderson clan in Virginia.

“Do not put off till tomorrow what can be put off till day-after-tomorrow just as well.” — Mark Twain

“Growing old ain’t for Sissies.” — Howard Anderson

I think both are fitting words for the inconvenience, effort and the amazing satisfaction that comes from giving your own blood, sweat, and sometimes a few tears to help researchers move us all one step closer to finding a ” Cure ” or high tech solutions that will improve the quality of life for persons living with T1D.  Last month I joined a new clinical trial at UVA’s Center for Diabetes Technology — my sixth trial since August 2010 — titled “Biobehavioral Mechanisms of Glucose Variability.”

Trial participants will track their insulin sensitivity results over about one month and travel to Charlottesville for an in-patient stay at UVA Hospital to measure,  through continuous blood analysis, how a person responds or counters a high and a low blood sugar. A greater understanding of these issues will help researchers, doctors and digital technology leaders finish key parts of the Artificial Pancreas project — a closed-loop insulin pump technology designed to better control glucose levels in T1 diabetics and reduce the serious medical complications of diabetes.

BarringerWingUVA

On a Saturday morning in October, I waited outside Barringer Wing at the old UVA Hospital complex for my health screening to start. It is always a very emotional and cool feeling for me to be back at Barringer — I’m walking the halls where my mother and father were on the day of my birth back in 1961.

Participating in a clinical trial is a volunteer labor of love. No one forces you to sign up. ( Attention: We need more people to sign up for clinical trials all over the world!! ). You are able to step out of a trial at any point. The truth is: it’s amazing to participate in cutting-edge medical technology like the AP and I’m hoping to benefit from the results of the research — automated glucose management that leads to better long-term health and less complications.

In a snapshot, here are the highlights of the first 3 weeks of my study. The BIG EVENT happens this week — when I complete my 12-hour in-patient stay at UVA hospital with the CDT medical team.

  • Week 1: Go to Lab Corp and get pre-trial blood work done and results shipped to UVA; Travel to Cville for health screen with medical team; Attach trial DexCom 4 Continuous Glucose Monitor (CGM); Go shopping at grocery store for pre-planned meals — breakfast, lunch, dinner and snack with exact carb, protein and fat grams — to be used for my 4 Insulin Sensitivity days; Do  “Twice” the number of normal finger sticks in order to record BG data in my trial meter and my own insulin pump meter — Ouch!
  • Week 2: Eat 2 tasty pre-packaged meals and record the exact food nutrition information on the spreadsheet provided by Stacey Anderson, MD — who is no relation to the Anderson clan but a cool coincidence that we share the same last name; Discover that the DexCom CGM sensor applicator — does not always work and actually draws blood from my abdomen site; Keep doing the finger sticks — 9 to 10 times a day for two meters and for calibration of the CGM — Ouch!
  • Week 3:  Get day off from work approved; Discover that the ” hidden gem ” of the trial study is NOT going to happen yet — wearing the DexCom5 CGM prototype in addition to the DexCom 4 CGM; The DexCom 5 is being manufactured specifically to work directly with the Artificial Pancreas SmartPhone — delivering blood glucose results to the SmartPhone and not to the normal CGM receiver. This is one of the remaining “closed-loop” research items to be completed before the AP can become commercially available.

For now, that’s my story. Stay tuned for my next blog post and photos — from the in-patient glucose variability trial at UVA this coming week. Remember — We R the Cure. We R the ones who will make a brighter day for Type 1 diabetics.

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Author: werthecure01

Diabetes doesn't define me; it inspires me to define the future for individuals living with autoimmune diseases like Type 1 diabetes. -- Mike Anderson, diagnosed 1998.

4 thoughts on “The “Highs and Lows” Of Type 1 Diabetes Clinical Trials: Some Days You’re the Windshield; Some Days You’re The Bug

  1. Thanks for keeping us “in the loop”. This is so exciting and a true sacrifice on your part that will benefit so many. I look forward to reading more about your experiences.

  2. Thanks Mike for sharing these updates and for participating in the clinical trials. You are doing an awesome thing and your blog posts are great.

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